A method according to claim 1, wherein the salt of Mo-containing acid is one selected from the group consisting of alkali metal molybdates, alkali metal phosphomolybdates and alkali metal silicomolybdates. The above quaternary ammonium hydroxide compounds may be used in combination with sodium hydroxide, sodium phosphate, trimethylamine or triethylamine. A specific aspect of this invention deals with a spray-on composition to yield a conformable, solid, adherent coating without need to add an adhesive on biological sites which are 1 of irregular or have acute geometries; 2 difficult to reach; and 3 difficult-to- adhere to tissues, such as wet mucous membranes. It was noted to yield a transparent, breatheable film that seals applications site from water, dirt, and germs for maximum protection. The drying time was predetermined in a pilot experiment to insure that the drying process resulted in a constant film weight.
Nobecutane sprayed on a wound forms a plastic film which serves as a dressing material. A tissu e protecting, spray-on film composition as in claim 1 comprising an essentially A-B diblock chain structure, wherein the A-block is derived from n-hexyl methacrylate and wherein the B -block is derived from a monomer selected from the group consisting of N- vinyl pyrrolidone, 2-hydroxyl ethyl methacrylate, acrylamide, and N-methyl acrylamide. It was dissolved as a weight-percent solution in chloroform, precipitated in C methanol, poured onto a Teflon tray, and dried to constant weight. A tiss lie protecting, spray-on film composition as in claim 1 comprising an essentially B-A-B triblock chain structure wherein the A-block is derived from a monomer selected from the group consisting of TM-vinyl pyrrolidone, 2-hydroxy ethyl methacrylate, acrylamide, and N-methyl acrylamide and the B-blocks are derived from at least one alkyl methacrylate monomer selected from the group consisting of n-hexyl methacrylate and n-butyl methacrylate.
The film can contain a bioactive agent including those to have antimicrobial, anesthetic, anti-inflammatory, and wound-healing activities.
A method according to claim 5, wherein the salt of W-containing acid is one selected from the group consisting of alkali metal tungstates, alkali metal phosphotungstates and alkali metal silicotungstates. EXAMPLES 16 TO 22 Using the acrylamide concentrations, catalysts, reaction conditions and crystallization conditions shown in Table 1, reaction of acrylamide with formaldehyde or paraformaldehyde was carried out in the same manner as in Example 1. Acrylamide, a starting material, used in the present invention may be of any form of aqueous solution and crystal. The amount of the catalyst solution [sodium hydroxide content, 0. The dressing, which is permeable to both water vapor and oxygen, is impermeable to micro-organisms. The organic solvent includes methanol, ethanol, acetone and the like.
The polyurethane film is supported on a removable flexible carrier that can be drawn upon to provide a record of the size and shape of the wound to which the dressing is applied. The spray-on composition and hence, the resulting film may contain active compounds that 1 are capable of reducing pain, as in the case of local anesthetic agents which may include benzocaine at 0. This can be achieved by varying the film thickness and the ratio of the hydrophiphilic to hydrophobic component of the copolymer chain. When the pH is less than 6, bis-form products such as methylenebisacrylamide, diacrylamide dimethyl ether and the like are produced as by-products to remarkably lower the purity to the desired product.
The physical and biomechanical properties of these compositions are due to special chain design of the constituent copolymers wherein said chains comprise highly hydrophilic as well as highly hydrophobic segments or blocks. Claims 9 What is claimed is: 1. Further, the present invention has the following advantages: 1 Purification is easy because of few by-products formed. The amount of the aqueous solvent used is preferably such a one as giving about 30 to about 90 wt.
A tissue protecting, spray-on film composition as in claim 1 further comprising a biocompatible dye. Example 6. Naturally occurring and derivatized naturally occurring polymers have been tested as liquid adhesive coatings for bandage applications and, in some cases, utilized commercially. A disinfectant spray bandage composition as in claim 18 that is a precursor of a clear film comprising at least 0.
Additionally, the barrier film dressing is permeable to both water vapor and oxygen, but is impermeable to micro- organisms. Typical examples are nitrocellulose in various solvents e. An increased amount of the bis-form products makes it difficult to use the desired product as a polymerized product because the solubility of the polymerized product remarkably lowers. A method according to claim 5, wherein the salt of W-containing acid is one selected from the group consisting of alkali metal tungstates, alkali metal phosphotungstates and alkali metal silicotungstates.