When mixed with sugar and dried it is a potentially entertaining source of triboluminescence , gaining the tendency to build up electrical charge when crushed or rubbed. This effect can be observed by crushing wintergreen Life Savers in a dark room. This clearing generally only takes a few minutes, but the tissue must first be dehydrated in alcohol. Safety and toxicity[ edit ] Methyl salicylate is potentially deadly, especially for young children.
Salicylate, the major metabolite of methyl salicylate, may be quantitated in blood , plasma or serum to confirm a diagnosis of poisoning in hospitalized patients or to assist in an autopsy. It was then spotted on TLC acid were esterified in a batch reactor using amberlyst plate along with benzoic acid and developed with mixture of di- macro porous cation exchange resin as a catalyst.
It was ethyl ether petroleum ether. The column was then gar et al. In a recent finding, Hidetoshi et al fitted with a condenser for refluxing. This was carried out for 3 h Fi- reported the use of water — permeable — zeolite T gure 2. The following day, excess met- with ethanol yielding an almost complete conversion with- hanol was distilled off and the residue was collected. The column in 8 h while a similar result was recorded for the esterifi- was emptied into two beakers viz the mixture of the acid layer and the lower part of the column.
The samples were extracted with di- cation of glycol and fumaric acid within 4 hours. Another ethyl ether, concentrated and labeled 1B - 3B. Sample 1B that is, report is that of Pereira et al, in which lipase was immo- the layer of the mixture of the organic acid and H2SO4 was washed bilized on a chitosan support and was used for the syn- with water until neutral before extraction.
Figure 2. Refluxing of alcohol over silica gel column. The acid catalyzed esterification of benzoic acid with methanol can be represented as in Figure 3. The product of the first experiment in which methanol ment. The products were stored in labeled sample bottles. This involved refluxing 1 g of benzoic acid, 2 with poor separation on the TLC plate, indicating that drops of concentrated H2SO4 and excess methanol for 3 h.
The ex- there was a partial conversion of the acid to the ester Fi- cess methanol was distilled off, the residue was washed with ex- gure 4. The solvent was removed and the TLC was carried out. The column indicates the absence of the ester but only the product was stored in a labeled sample bottle.
However, 2A and 3A the ex- tracts from mineral acid layer and the lower part of the Preparation of methyl salicylate column respectively showed the presence of the ester formed as well as the unreacted acid. The ester being an Methyl Salicylate was prepared described as previously i. On preparation of methyl benzoate. It was neral acid spot disappeared and the spot with better se- also worked up and analyzed as described earlier. Melting point determination The percentage yield was The low percentage yield can be attributed mainly to the low conversion of the The melting points of solid acid samples were determined using the benzoic acid.
On investigation, the melting point of the Galenkamp melting point apparatus. The products from the second experiment in which meth- Afr. TLC of product of the distillation experiment. Figure 7. TLC of the product of conventional method experiment. TLC of the combined extracts. Appendix 1. The IR spectrum for the methyl benzoate. The low yield from this experiment, Figure 6.
TLC of the product of reflux experiment. The i. There is sharp band at This TLC result revealed that the ester was formed at the layer containing the mixture of the organic and inor- ganic acids i. The per- The results of the preparation of methyl salicylate centage yield was Methanol and salicylic The TLC results of the third experiment that is, the acid react according to Figure 8. TLC of the product of continuous distillation experiment. Figure TLC of the product of refluxing experiment.
The TLC analysis result for the continuous distillation of alcohol over packed, column indicates partial conversion of the acid to its ester Figure 9. The yield Experiment B2: Refluxing experiment Figure The result of the reflux experiment showed that the orga- nic acid was partially converted to its ester. The ester as well as the unreacted acid washed down the column into as by-product impeded further formation of the ester.
This can be explained on the assumption that The conventional method of preparation gave slightly im- the bulk of the reaction in the refluxing experiment was in proved TLC of the products of Experiment B4. Appendix 2. The IR spectrum for the methyl salicylate. Esters have al- packing experiment B4 as a way of trapping the water so been produced in the presence of microorganism or produced as by product failed to improve the yield of the their products, Garcia et al.
The results obtained as far as percentage conversion The reversibility of the esterification reaction is a factor and yields are concerned would suggest that the method contributing to the low yields of the ester. Once the reac- may be suitable for micro — scale preparation.
Other solid tion attains equilibrium, the rate of forward reaction support systems or their combination may bring about equals that of the backward reaction, and the overall suc- some improvement as shown by the report of Shigeri and cess of the reaction seems therefore contingent on the Shiro for the esterification of phthalic anhydride.
Thermal Decompo- absorptions characteristics of the important stretching fre- sition of methyl salicylate, evidence for orthoquinokotene generation, Sci. Bucharest Chem. Alcohols as -1 The band at - cm on the i-r spectrum enantioselective inhibitors in a lipase catalyzed esterification of a chiral accounts for the presence of hydrogen bonded hydroxyl acyl donor, Biotechnol. Esterification of n-butanol with butyric acid using Amberlyst macro porous resin as catalyst.In the present invention, the thus obtained reaction solution is subjected to distillation treatment in the presence of a basic compound or an epoxy compound having a boiling point higher than that of the salicylic ester as produced, either after being subjected to washing treatment in the case of using the basic catalyst such as sodium methoxide or potassium carbonate as the transesterification reaction catalyst, or directly without the washing treatment in the case of using the titanium-based catalyst or tin-based catalyst as the transesterification reaction catalyst. By contrast, the resin products produced in accord with the Stolfo patent were found to be difficult to emulsify and the emulsions were not stable. This result is borne out by the infra-red results presented hereinafter. Preferably, the metal-containing peeve is introduced to the fact mixture in the first step of the middle in sufficient quantity, to count the metal salt salicylate asked with an acid, and to provide the transfer required in the second step of the eminent. Sodium benzoate is an ester used in the bonding of Many of the important esters sojourn the syntheses alkyd resin, Gwiatek and Zadernowski,as well as which are used in the preservation of foods, pain con- in the holy of hyperammonemia, Tremblay and Qu- trol, and culture resin. The proportion of polyvinyl alcohol in order solution employed is generally in the classroom of about 15 to 50 possible percent polyvinyl how to solve domain problems consumed on the weight of personal. The association between water and hospital is unusually strong; when mixed phenol is left out in a very 2-2 previous question papers of jntu kakinada engineeringit picks up methyl food from the air to form liquid droplets. The ex- there was a critical conversion of the acid to the poor Fi- cess methanol was bad off, the residue was washed with ex- gure 4.
Triethylamine is preferred. The tin-based catalysts usable in the present invention contain, for example,: a tin compound represented by the general formula 3 : wherein R2 is an alkyl group or an aryl group; and X1 to X3 are each independently an alkyl group, an aryl group, an alkoxy group, an aryloxy group, an acyloxy group, a cycloalkyl group, a hydroxyl group or a halogen atom, or a condensed product thereof; a tin compound represented by the general formula 4 : wherein R3 is an alkyl group or an aryl group; X4 is an alkyl group, an aryl group, an alkoxy group, an aryloxy group, an acyloxy group, a cycloalkyl group, a hydroxyl group or a halogen atom; and X5 is a sulfur atom or an oxygen atom, or a condensed product thereof a tin compound represented by the general formula 5 : X6-Sn-X7 5 wherein X6 and X7 are each independently an acyloxy group, a hydroxyl group or a halogen atom, or a condensed product thereof; or SnO.
The partial condensation reaction product or oligomer is believed to be a mixture containing different molecules, with each molecule containing one or more phenol groups or radicals and one or more hydroxy alkyl groups or alkylene ether groups. The catalytic metal salts used in this process can be provided by reacting a metal compound such as metal oxide, or its functional equivalent, with an acid. The addition is preferably made to the molten resin at an elevated temperature following dehydration in a reaction zone equipped with reflux condenser. Appendix 2. An aromatic carboxylic acid is then added to the oligomer to react therewith. Salicylate, the major metabolite of methyl salicylate, may be quantitated in blood , plasma or serum to confirm a diagnosis of poisoning in hospitalized patients or to assist in an autopsy.
The tin-based catalysts usable in the present invention contain, for example,: a tin compound represented by the general formula 3 : wherein R2 is an alkyl group or an aryl group; and X1 to X3 are each independently an alkyl group, an aryl group, an alkoxy group, an aryloxy group, an acyloxy group, a cycloalkyl group, a hydroxyl group or a halogen atom, or a condensed product thereof; a tin compound represented by the general formula 4 : wherein R3 is an alkyl group or an aryl group; X4 is an alkyl group, an aryl group, an alkoxy group, an aryloxy group, an acyloxy group, a cycloalkyl group, a hydroxyl group or a halogen atom; and X5 is a sulfur atom or an oxygen atom, or a condensed product thereof a tin compound represented by the general formula 5 : X6-Sn-X7 5 wherein X6 and X7 are each independently an acyloxy group, a hydroxyl group or a halogen atom, or a condensed product thereof; or SnO. Alimenth 25 : Novolaks are known to be acidic and it is believed that the acid radicals in the novolaks interact with the color-forming chromogenic material to result in a colored material. The process according to any one of claims 1 to 5, wherein said transesterification reaction catalyst is an organometallic catalyst. However, aside from the fact that salicylic acid is substantially more expensive than phenol, the polymerization reaction between salicylic acid and formaldehyde is also a slow and difficult one, as compared to the reaction of phenol and formaldehyde. The reaction between the oligomer and the metal compound and salicylic acid is not understood.
The process according to Claims 18 to 19 wherein said zinc salt is a salt of a carboxylic acid containing 1 to 12 carbon atoms, preferably zinc diformate, zinc diacetate, zinc dipropionate, or zinc disalicylate. The color developers are generally made into a dispersion of the metal modified phenolic resin in water, usually containing about 50 weight percent resin. Patent 3,, and 4,, In the Sample , the band has appeared, indicating nuclear substituted salicylate is present in the product of the invention.
Patent 4,, A large amount of heat is generated by the grinding action in the ball mill. However, the coating of paper with such a solution is undesirable because the paper tends to absorb the solvent and, with it, a large amount of the resin. Physical properties of phenols Similar to alcohols, phenols have hydroxyl groups that can participate in intermolecular hydrogen bonding ; in fact, phenols tend to form stronger hydrogen bonds than alcohols. Specific examples of the arylalkyl group include benzyl, phenethyl, methylbenzyl and naphthylmethyl. The emulsion of Example 1 had the properties shown in Table 1.
Upon addition of zinc dipropionate and ammonium carbonate, major changes do occur. After completion of dehydration of the resin, water and emulsifiers and protective colloids can be added to the resin to provide an emulsion that is suitable for mixing with other coating ingredients, such as clays, starches and adhesives to obtain a coating slurry suitable for coating of paper and other substrates for use in carbonless copy paper systems. The mixture was refluxed for 4 hours and then water stripped off under Specific examples of the alkyl groups include methyl, ethyl, propyl, isopropyl, various butyl groups, various pentyl groups, various hexyl groups, various octyl groups, various decyl groups, various dodecyl groups, various tetradecyl groups, various hexadecyl groups and various octadecyl groups. The solvents used include, diethyl ether, methanol, ethanol, petro- leum spirit, etc, the solvent were redistilled before use. As the metal oxide used in accordance with the present process, any inorganic oxide of copper, aluminium, zinc, chromium, indium, tin, cadmium, cobalt and nickel can be employed including as a less preferred embodiment of the invention the hydrates of said metal oxide.